A research study into understanding the management of pregnancies with intrahepatic cholestasis of pregnancy (ICP).

This study has ended


Intrahepatic cholestasis of pregnancy (ICP – sometimes also known as obstetric cholestasis or OC), is a liver disorder that affects 1 in 200 pregnancies.

For more information about ICP, go to www.icpsupport.org

What did the study find?

The study looked at the effects on the baby of having severe ICP during pregnancy. It found that women who had severe ICP were more likely to have a stillborn baby, to deliver their baby early or have a baby who needed support in the neonatal unit. Most of the women whose babies were stillborn had other pregnancy complications, so the results are not completely straightforward. But they are clear enough to show that women who have severe ICP in pregnancy need closer monitoring than women without it.

Who conducted the research?

This study was run through Wellbeing of Women, the charity arm of the Royal College of Obstetricians and Gynaecologists (RCOG).

The project team, led by Professor Catherine Williamson at the Institute of Reproductive and Developmental Biology, Imperial College London.


The findings from this study have been published in the journal Hepatology.

Geenes V, Chappell LC, Seed PT, Steer PJ, Knight, M, Williamson C. Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study. Hepatology 2014;59:1482–91.


This study has ended

Grant awarded


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